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The acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP/IAN genes links the innate immune responses of corals with those of mammals and plants

机译:珊瑚Ac虫对免疫挑战的急性转录反应:GiMAP / IAN基因的表达将珊瑚与哺乳动物和植物的固有免疫反应联系在一起

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摘要

Background: As a step towards understanding coral immunity we present the first whole transcriptome analysis of the acute responses of Acropora millepora to challenge with the bacterial cell wall derivative MDP and the viral mimic poly I:C, defined immunogens provoking distinct but well characterised responses in higher animals.\ud\udResults: These experiments reveal similarities with the responses both of arthropods and mammals, as well as coral-specific effects. The most surprising finding was that MDP specifically induced three members of the GiMAP gene family, which has been implicated in immunity in mammals but is absent from Drosophila and Caenorhabditis. Like their mammalian homologs, GiMAP genes are arranged in a tandem cluster in the coral genome.\ud\udConclusions: A phylogenomic survey of this gene family implies ancient origins, multiple independent losses and lineage-specific expansions during animal evolution. Whilst functional convergence cannot be ruled out, GiMAP expression in corals may reflect an ancestral role in immunity, perhaps in phagolysosomal processing.
机译:背景:作为了解珊瑚免疫力的一个步骤,我们提出了第一例完整的转录组分析,分析了Acropora millepora对细菌细胞壁衍生物MDP和病毒模拟多聚I:C攻击的急性反应,这些免疫原引起了不同但特征明确的反应。结果:这些实验揭示了与节肢动物和哺乳动物的反应相似,以及珊瑚特有的作用。最令人惊讶的发现是MDP特异性诱导了GiMAP基因家族的三个成员,该成员与哺乳动物的免疫力有关,但果蝇和秀丽隐杆线虫不存在。像它们的哺乳动物同系物一样,GiMAP基因排列在珊瑚基因组中的串联簇中。\ ud \ ud结论:对该基因家族的系统生物学调查表明,其起源很古老,在动物进化过程中有多个独立的损失和谱系特异性扩展。尽管不能排除功能收敛,但珊瑚中GiMAP的表达可能反映了祖先在免疫中的作用,也许在吞噬体加工中。

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